Perimenopause Linked to Increased Psoriatic Arthritis Disease Activity
Perimenopause was linked to higher PsA disease activity and greater tender/swollen joint counts when compared with the pre- and postmenopausal stages.
Women with psoriatic arthritis (PsA) experience higher disease activity during the perimenopause transition compared with the pre- and postmenopausal stages, according to study results presented at the American College of Rheumatology (ACR) Convergence 2025, held from October 24 to 29, in Chicago, IL.
During perimenopause, fluctuating hormone levels and systemic changes may influence inflammatory conditions such as PsA.
While prior research has examined hormonal influences on autoimmune disease onset, limited evidence exists regarding how menopausal stages affect disease activity in PsA.
To address this knowledge gap, researchers conducted a longitudinal analysis using data from a prospective PsA cohort followed between 1978 and 2024 at the University of Toronto and affiliated centers.
Author summary: Perimenopause increases PsA disease activity.